Vaccination schedule in cattle and buffalo

Rabies (Post bite therapy only)

Infection

Manufacturer

Ingredients/adjuvant

Dose

Primary

Booster

Revaccination

FMD

Bovilis^®Clovax

Intervet India

Binary ethyleneimine (BEI) inactivated FMD mineral oil emulsion vaccine containing a mixture of virus serotypes O, A and Asia-1

2ml, i/m

(Vial: 100 ml)

3 months onwards

I After 4-6 weeks of primary vaccination

II After 24 weeks of first booster

Every 44-48 weeks after 2^nd booster vaccination

Raksha

Indian Immunologicals

Inactivated tissue culture FMD virus strains O, A and Asia-1 adsorbed on Al (OH)₃ gel and saponin as an adjuvant

3 ml in the mid-neck region, s/c

(Vial: 30 ml)

4 months

2-4 weeks after primary vaccination

Every 6 months after booster and every 4 months in endemic areas

Raksha Ovac

-do-

Inactivated tissue culture FMD virus strains O, A, and Asia-1 adjuvanted with mineral oil

2 ml  in the  mid-neck region, deep i/m

4 months

9 months after primary vaccination

Annually

Haemorrhagic Septicemia (Galghotu/Ghurrka)

Raksha HS

Indian Immunologicals

Formaldehyde inactivated culture of Pasteurella multocida adsorbed on aluminium hydroxide gel

2 ml, mid-neck region, s/c

(Vial:100 ml)

6 months and above

Annually and in adverse climatic conditions like unseasonal rains and cyclones, etc.

Compound Vaccines of FMD/HS/BQ

Raksha biovac

(FMD+HS)

Indian Immunologicals

FMD inactivated antigens against O, A, and Asia-1 strains and formaldehyde inactivated Pasteurella multocida culture mixed together in light mineral oil emulsion

3 ml, midneck, deep i/m

(Vial: 30 ml)

4 months

9 months

Annually

Raksha triovac

(FMD+HS+BQ)

-do-

FMD inactivated antigens against O, A, Asia-1 and formaldehyde inactivated Pasteurella multocida culture, inactivated Clostridium chauvoei culture mixed together in light mineral oil emulsion

3 ml, mid-neck, deep i/m

(Vial: 30 ml)

4 months

9 months

Annually

Raksha HS+BQ

-do-

Formaldehyde inactivated cultures of Pasteurella multocida and Clostridium chauvoei adsorbed on aluminium hydroxide gel

3 ml, mid-neck region, s/c

(Vial: 90 ml)

6 months and above

Annually and in  adverse climatic conditions like unseasonal rains and cyclones, etc.

Brucellosis

Bruvax

Indian Immunologicals

Live Brucella abortus strain 19 freeze dried bacteria, each dose ≥ 40x10⁹ organisms

2 ml., s/c

(Vial: 5 dose freeze dried vaccine with 10 ml sterile diluent)

4-8 months old serologically negative female calves

Note:Only serologically negative female calves should be vaccinated with live B. abortus strain 19 while bulls and pregnant animals should not be vaccinated

Depending upon prevalence in a given area, vaccination against following diseases may also be taken up Anthrax

Raksha-Anthrax

(Prophylactic only)

Indian Immunologicals

Suspension of live spores of attenuated non-capsulated strain of B. anthracis in 50% glycerinated saline, each dose ≥ 1x10⁸ viable spores

1 ml, i/m or s/c

(Vial: 50 ml)

one month before grazing season or prior to the time the disease usually occurs

Note:  Protect animals from overexertion 3 days following vaccination. Do not vaccinate the animal 60 days before slaughter

Sterne Vaccine

Institute of Veterinary Preventive Medicine, Tamil Nadu

**Live spores of highly antigenic nonencapsulated avirulent Sterne strain (34 F2) of B. anthracis in glycerine saline

1 ml, s/c

Approx. 4 weeks prior to the time the disease usually appears

Revaccinate after 2-3 weeks in heavily contaminated areas

annual vaccination in endemic areas

Note:  Use boiled milk from lactating animals up to 1 month after vaccination, do not vaccinate within 42 days before slaughter, do not give antibiotics to animals being vaccinated; burn, autoclave or chemically disinfect container and all unused contents; adrenalin should be administered immediately if anaphylactoid reaction occurs, immunity 6m-1year

Rabies

Raksharab, Prophylactic

Indian Immunologicals

***Tissue culture rabies virus, CVS strain adjuvanted with Al(OH)3 adjuvant, antigen potency >2.5 IU/ml

1 ml by s/c or i/m route

(Vial: 1 ml, 5 ml, 10 ml)

3 m and above

In case primary vaccination is given below 3 months of age, a booster dose should be given at 3 months age

3 years, annual vaccination recommended in endemic areas

Post-exposure therapy (PET)

I-Day Zero of dog bite or  within 24 hrs, II-Day 3, III-Day 7, IV-Day 14, V- Day 28 and VI-Day 90

Note:  Vaccinate only healthy animals; malnutrition, helminth infestation, administration of immunosuppressive agents like corticosteroids, radiation therapy, etc. will suppress immune response to vaccine; generally no adverse reactions are noticed, occasionally a transient, palpable nodule may occur at the site of injection; in rare cases hypersensitivity may occur, immediate treatment with antihistaminics is advocated.